感染、炎症、修复

参考文献

[1]国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2020:315-316.

[2]杨珊,赵暖暖,杨鑫,等.人参活性成分及药理作用研究进展[J].中医药导报,2023,29(1):105-107.

[3]马传贵,张志秀,王琦.人参皂苷抗肿瘤及免疫调节作用的研究应用进展[J].特种经济动植物,2024,27(3):182-185.

[4]张玉姣,王霞,孙孟琪,等.人参化学成分与应用的研究进展[J].农业与技术,2024,44(14):10-14.

[5]崔庆丽.基于网络药理学探讨人参挥发性成分治疗胃癌的作用机制研究[D].南京中医药大学,2022.

[6]张亚杰.人参亚临界水提取物的化学成分及抗氧化活性研究[D].北京林业大学,2018.

[7]汪丫婷,王宇阳,周丽洁,等.人参对肺癌多种通路的影响及机制探析[J].云南中医中药杂志,2024,45(7):85-89.

[8]DAI T Y,LAN J J,GAO R L,et al.Panaxdiol saponins component promotes hematopoiesis by regulating GATA transcription factors of intracellular signaling pathway in mouse bone marrow[J].Ann Transl Med,2022,10(2):38.

[9]WEN W W,SUN X,ZHUANG H F,et al.Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation,differentiation and corresponding gene expression profile of megakaryocytes[J].Chin J Integr Med,2016,22(1):28-35.

[10]ZHANG A P,GAO R L,YIN L M,et al.Panoxadiol saponins Induce upregulation of MAPK/ERK signal pathway in bone marrow cells of aplastic anemia mice[J].Chin J Pathophysi(Chin),2018,34:686-692.

[11]LIU Y,DENG J J,FAN D D,et al.Ginsenoside Rk3 ameliorates highfat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway[J].Food Funct,2019,10(5):2538-2551.

[12]YANG S W,LIU T,HU C X,et al.Ginsenoside compound K protects against obesity through pharmacological targeting of glucocorticoid receptor to activate lipophagy and lipid metabolism[J].Pharmaceutics,2022,14(6):1192.

[13]LEVY M J F,FABIEN B,STEINBUSCH H W,et al.Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression[J].Psychopharmacology (Berl),2018,235(8):2195-2220.

[14]MARSDEN W N.Synaptic plasticity in depression:molecular,cellular and functional correlates[J].Prog Neuropsychopharmacol Biol Psychiatry,2013,43:168-184.

[15]DUMAN R S,AGHAJANIAN G K,SANACORA G,et al.Synaptic plasticity and depression:new insights from stress and rapid-acting antidepressants[J].Nat Med,2016,22(3):238-249.

[16]WANG G L,AN T Y,LEI C,et al.Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the mi R-134-mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression[J].J Ginseng Res,2022,46(3):376-386.

[17]YANG X,CHU S F,WANG Z Z,et al.Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways in the striatum[J].Acta Pharmacol Sin,2021,42(9):1409-1421.

[18]ZHANG S,SHEN S H,MA P,et al.Biochemical targets and molecular mechanism of ginsenoside compound K in treating osteoporosis based on network pharmacology[J].Int J Mol Sci,2022,23(22):13921.

[19]YANG S,LI F Y,LU S Y,et al.Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-k B signaling pathway and activating autophagy and p62-Nrf2-Keapl signaling in vitro and in vivo[J/OL].J Ethnopharmacol,2022,283:114739[2022-01-30].https://pubmed.ncbi.nlm.nih.gov/34648903/.DOI:10.1016/j.jep.2021.114739.

[20]BORJA M,PATRICIA M,RAFAEL B M,et al.Effect of ginseng intake on muscle damage induced by exercise in healthy adults[J].Nutrients,2024,16(1):90.

[21]许红琳.基于TLR4/NF-κB/MAPK信号通路探讨人参及其活性成分抑制脂多糖诱导小鼠急性肺损伤的作用及机制研究[D].南方医科大学,2022.

[22]李炳辉,邹新华,李恭驰,等.2019年糖尿病足基础及临床研究进展[J].感染、炎症、修复,2020,21(1):11-15.

[23]KIMURA Y,SUMIYOSHI M,KAWAHIRA K,et al.Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice[J].Br J Pharmacol,2006,148(6):860-870.

[24]PAZYAR N,YAGHOOBI R,RAFIEE E,et al.Skin wound healing and phytomedicine:A review[J].Skin Pharmacol Physiol,2014,27(6):303-310.

[25]汲鹏.人参总皂苷通过调节PHD2/HIF-1α/EPO信号通路改善高海拔缺氧所致肺和肾组织损伤[D].长春中医药大学,2024.

[26]TIAN M,MA P,ZHANG Y,et al.Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway[J/OL].Int Immunopharmacol,2020,85:106645[2020-08-13].https://pubmed.ncbi.nlm.nih.gov/32521491/.DOI:10.1016/j.intimp.2020.106645.

[27]梁文菲,张熙,彭阿建,等.人参皂苷Rg1对高糖环境下人脐带血间充质干细胞分泌炎症因子水平的影响[J].山东医药,2021,61(26):21-24.

[28]ZHANG K,LI J C,SHI Z,et al.Ginsenosides regulates innate immunity to affect immune microenvironment of AIH through hippo-YAP/TAZsignaling pathway[J/OL].Front Immunol,2022,13:851560[2022-12-11].https://pubmed.ncbi.nlm.nih.gov/35222444/.DOI:10.3389/fimmu.2022.851560.

[29]QU L L,ZHU Y Y,LIU Y N,et al.Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation,oxidative stress,and apoptosis[J].Food Chem Toxicol,2019,126:277-284.

[30]GUAN S B,XIN Y F,DING Y G,et al.Ginsenoside Rg1 protects against cardiac remodeling in heart failure via SIRT1/PINK1/Park in-mediated mitophagy[J/OL].Chem Biodivers,2023,20(2):e202200730[2023-01-24].https://pubmed.ncbi.nlm.nih.gov/36639922/.DOI:10.1002/cbdv.202200730.

[31]LIU T H,ZUO L,GUO D Q,et al.Ginsenoside Rg3 regulates DNAdamage in non-small cell lung cancer cells by activating VRK1/P53BP1pathway[J/OL].Biomed Pharmacother,2019,120:109483[2019-12-12].https://pubmed.ncbi.nlm.nih.gov/31629252/.DOI:10.1016/j.biopha.2019.109483.

[32]ZHANG Y,M A P,DUAN Z G,et al.Ginsenoside Rh4 suppressed metastasis of lung adenocarcinoma via inhibiting JAK2/STAT3signaling[J].Int J Mol Sci,2022,23(4):2018.

[33]HU M L,YANG J,QU L L,et al.Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κBpathway in lung adenocarcinoma[J].Food Funct,2020,11(1):456-471.

[34]AN X N,FU R Z,MA P,et al.Ginsenoside Rk1 inhibits cell proliferation and promotes apoptosis in lung squamous cell carcinoma by calcium signaling pathway[J].RSC Adv,2019,9(43):25107-25118.

[35]ZHU H,HE Y S,MA J,et al.The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice[J].J Ethnopharmacol,2021,265:113271[2021-01-30].https://pubmed.ncbi.nlm.nih.gov/32853742/.DOI:10.1016/j.jep.2020.113271.

[36]LIU Y N,FAN D D.Ginsenoside Rg5 induces G2/M phase arrest,apoptosis and autophagy via regulating ROS-mediated MAPKpathways against human gastric cancer[J].Biochem Pharmacol,2019,168:285-304.